Hollis is a census-designated place on Prince of Wales Island in Prince of Wales-Hyder Census Area, Alaska, United States. At the 2020 census the population was 65, down from 139 in 2000. According to the United States Census Bureau, the CDP has a total area of 64.6 sq mi, of which, 63.2 sq mi of it is land and 1.4 sq mi of it is water.