Wilkinson County is a county located in the southwest corner of the U.S. state of Mississippi. As of 2020, its population was 8,587. Its county seat is Woodville. Bordered by the Mississippi River on the west, the county is named for James Wilkinson, a Revolutionary War military leader and first governor of the Louisiana Territory after its acquisition by the United …Wilkinson County is a county located in the southwest corner of the U.S. state of Mississippi. As of 2020, its population was 8,587. Its county seat is Woodville. Bordered by the Mississippi River on the west, the county is named for James Wilkinson, a Revolutionary War military leader and first governor of the Louisiana Territory after its acquisition by the United States in 1803.