When it comes to drafting 49ers running back Christian McCaffrey in 2025 Fantasy Football leagues, you'll find a lot of skepticism. Too many Fantasy Football managers have been burned by McCaffrey, as recently as the 2024 season when some took him as early as No.

Derrick Henry and Christian McCaffrey remain fantasy football elites, but one is a safer and smarter pick in 2025—find out who should anchor your draft.

Make of them what you will, but here are the stats from last season that you should be aware of as you prepare for your drafts.