(C) A549 cells were transfected with a p53:MDM2 NanoBRET Protein-Protein Interaction pair and frozen for later use. Transfected cells displayed high levels of cell viability post-thaw.

Methods: Xenografts (p53 wild type [wt] A549, p53 mutant H1299 and p53 null Calu6) were generated in the leg of nude mice by i.m. injection of 1- 5 X 10 6 tumor cells grown in vitro. Tumors were ...

CLSP-1025 targets the p53 R175H mutation, which is prevalent in a range of solid tumors such as colorectal, esophageal, gastric, gynecological, lung, pancreatic and prostate cancers.

Frontier Medicines Unveils New Preclinical Data for FMC-220, a First-in-Class Covalent p53 Y220C Activator, at AACR 2025 ...