“The tropism of natural AAV serotypes is limited,” he says. “They also tend to infect the liver, which can cause severe side effects in some cases.” Improving AAV tropism could offer ...

Simply put, AAV consists of a protein shell ... with decreased transduction of the liver. Further, we’ve seen cross-species CNS tropism (including rodents and multiple non-human primate species ...

Underpinning Voyager’s mission is its trademark AAV capsid-discovery platform ... promise for producing candidates with enhanced tropism for liver, eye, and other tissue types (Fig.

AI-assisted AAV capsid engineering has transformative potential in terms of accelerating and optimizing the development of gene therapies.

Researchers prefer AAV vectors due to their broad tissue tropism, high safety profile ... central nervous system (CNS), lungs, retina, liver, pancreas, kidney, and heart. Natural AAV mutants ...