most effectively reduced CAR T cell proliferation and target cell death. “Traditionally, a lot of these synNotch receptors have been applied to get better tumor cell killing or [activate] a stronger ...

Macrophages interact with T cells in order to bring about T cell activation in target organs, and are themselves activated by inflammatory messenger ... for developing macrophages that control T-cell ...

Imagine a super-charged immune cell that can launch a focused attack on stubborn solid tumors—a smart fighter that destroys ...

Researchers at the Francis Crick Institute have shown that the entry of water into immune cells, such as T cells, is a key requirement for their activation and proliferation when responding to ...

Early clinical results suggest the firm's antibodies targeting the Vβ T-cell receptor could induce strong and durable responses in cancer patients.

M@P can promote the production of tumor-specific antigens and the maturation of dendritic cells, leading to the proliferation of activated T cells, thereby inducing a robust systemic antitumor ...

Perpetuation then results from the effects of these stimuli on maintaining the activated phenotype and generating fibrosis. The earliest changes in stellate cells are likely to result from ...

Mammalian AMP-activated protein kinase (AMPK ... It also inhibits cell growth and proliferation by triggering phosphorylation events that inhibit the TOR (target of rapamycin) pathway and cause ...

Breast cancer is one of the leading causes of mortality among women worldwide. Tumor necrosis factor α-induced protein 3-interacting protein 1 (TNIP1) is a ubiquitin-binding protein that is widely ...