Ad5 vectors are the most commonly used adenovirus vector. Ad5 vectors transduce a wide range of cell types. They utilize the Coxsackie-Adenovirus Receptor (CAR) to enter cells. Transduction efficiency ...

First generation vectors may be suitable for applications where transient, high level activity is sufficient, and where immune responses to the vector or transgene are acceptable. Adenoviral vectors ...

At the height of the COVID-19 pandemic in 2021, VITT emerged as a new disease following adenovirus vector-based vaccines—notably the Oxford-AstraZeneca vaccine. VITT was found to be caused by an ...

The adenovirus vector, for example, can be grown up in cells and used for various vaccines. Once you make a viral vector, it is the same for all vaccines, says Florian Krammer, a vaccinologist at the ...

Bladder cancers (BCs) that invade the muscle layer are classified as muscle-invasive bladder cancers (MIBCs). The MIBC subtype accounts for around 25% of all BC cases, with a significant proportion of ...

They engineered an adenoviral vector to include a repressor protein (TetR) and its binding site (tetracycline operator, TetO) in the MLP. Adding these two elements means that once the MLP is ...

clearance rate of 60% and highest cervical clearance rate of 67% was seen in the group that received the highest dose of chimpanzee adenovirus vector (ChAdOx) vector - a component of VTP-200 ...

Investigators from Insmed Inc. have presented new preclinical data on the efficacy of their adenoviral vector (AAV9)-based gene therapy INS-1201 for the treatment of Duchenne muscular dystrophy (DMD).

with helper adenovirus infection enabling vector production in mammalian cells. This method offered good proof-of-concept, but was too inefficient for large-scale manufacturing. What’s more ...

Immunotherapy has emerged as one of the major options for cancer treatment in the past decade. With the successful application of immune checkpoint inhibitors and the introduction of immune regulatory ...