Ad5 vectors are the most commonly used adenovirus vector. Ad5 vectors transduce a wide range of cell types. They utilize the Coxsackie-Adenovirus Receptor (CAR) to enter cells. Transduction efficiency ...

First generation vectors may be suitable for applications where transient, high level activity is sufficient, and where immune responses to the vector or transgene are acceptable. Adenoviral vectors ...

They engineered an adenoviral vector to include a repressor protein (TetR) and its binding site (tetracycline operator, TetO) in the MLP. Adding these two elements means that once the MLP is ...

The COVID-19 pandemic demonstrated that the mass production of vaccines is crucial for our healthcare system. In order to ...

New conditionally replicative adenovirus vector with synNotch receptor gene for MIBC treatment March 25, 2025 The MIBC subtype accounts for around 25% of all BC cases, with a significant proportion of ...

with helper adenovirus infection enabling vector production in mammalian cells. This method offered good proof-of-concept, but was too inefficient for large-scale manufacturing. What’s more ...

Pacira BioSciences begins patient dosing in phase 2 study evaluating safety and efficacy of PCRX-201 to treat osteoarthritis of the knee: Brisbane, California Saturday, April 5, 2 ...