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In summary, although the mechanism connecting obesity to adipose tissue inflammation has long been enigmatic, this current work demonstrates that SirT1 can sense nutrient status and directly ...

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The findings were published in Journal of Translational Medicine. When people gain weight, their adipose tissue expands, which gradually leads to its inflammation, and to insulin resistance.

This adipose tissue plays important immunological roles, but can also serve as a source of chronic inflammation in obese individuals, possibly contributing to metabolic syndrome.

The study found that obesity-induced adipose tissue inflammation increased the secretion of extracellular vesicles, which may contribute to the detrimental health effects of obesity.

Mac1 were resident to the tissue in both lean mice on a normal diet and obese mice. Mac2 and Mac3, which were identified by their pro-inflammatory genes, peaked after eight weeks of the high-fat diet.