An investigational monoclonal antibody appeared to have therapeutic benefits among kidney transplant patients with antibody-mediated rejection, a randomized phase II trial showed. After 24 weeks ...

Rutgers Health researchers and other medical scientists involved in a large international study have identified new signs of kidney transplant ... signs of antibody-mediated rejection.

“Antibody-mediated rejection remains a significant challenge in kidney transplantation, with limited safer and effective treatment options currently available. With the potential to be disease ...

Towana Looney lived with the kidney longer than any other transplant patient had tolerated an organ from a genetically ...

Biogen has announced that it has initiated a late-stage study of felzartamab in adult kidney transplant recipients who have been diagnosed with late antibody-mediated rejection (AMR). The phase 3 ...

Surgeons at NYU Langone Health in New York City had to remove a genetically modified pig kidney from Towana Looney, 53, of Gadsden, Ala., because her body rejected the organ. She's back on dialysis.

Hyperacute rejection is an antibody-mediated cytotoxic ... in the operating room; the kidney frequently turns black before the surgical team's eyes. Antibody-to-transplant antigens can develop ...

2 Since 1986, over 117 monoclonal antibodies have been FDA-approved, beginning with the mouse monoclonal antibody Muromonab-CD3 for kidney transplant rejection. 3 In additional to antibodies from mice ...

The transplantation of allogeneic ... and via direct complement-dependent, antibody-mediated cytotoxicity. B cells play a critical role in skin allograft rejection by promoting the differentiation ...

“Antibody-mediated rejection remains a significant challenge in kidney transplantation, with limited safer and effective treatment options currently available. With the potential to be disease ...

The Phase 3 study will evaluate the efficacy and safety of the investigational drug felzartamab compared to placebo in adult kidney transplant recipients diagnosed with late antibody-mediated ...