Back in August 2002, the Azumanga Daioh anime aired its 20th episode ... imagines herself just landing in the United States and seeing every American as a tiny version of her friend Chiyo Mihama ...
Azumanga Daioh is one of the most iconic anime to come out of the 2000s, and decades later, it's made its return in a truly unexpected way.
Note: There will be spoilers for the Azumanga Daioh crossover with Yotsuba below. Leaker ryokutya2089 shared the information without revealing what the exact contents of the crossover are.