Bilirubin, a by-product of haem metabolism, plays a crucial role in human physiology beyond its well-known association with jaundice. Emerging evidence underscores its antioxidant and cell ...

The metabolism of bilirubin begins with its production from heme in the spleen and bone marrow, followed by transportation to the liver, where it undergoes enzymatic conversion. The liver plays a ...

The metabolism of bilirubin begins with its production from heme in the spleen and bone marrow, followed by transportation to the liver, where it undergoes enzymatic conversion. The liver plays a ...

Under normal conditions, bilirubin formed from the catabolism of heme is taken up and conjugated by the liver, secreted into the bile and then transported through the bile ducts to the duodenum.

Other interventions are designed to limit bilirubin production, enhance its metabolism and excretion, or both (Table 1). Of these interventions, metalloporphyrin inhibition of heme oxygenase ...

future research can now focus on the extent to which gut microbial bilirubin metabolism affects… the role of bilirubin reduction in health and disease,” the researchers said in the same study.

Further research is needed to fully understand the mechanisms by which BilR and other gut microbial enzymes influence bilirubin metabolism and their broader implications for human health ...

"The gene variant codes for an enzyme that has not previously been linked to the metabolism of bilirubin. Although the enzyme itself does not protect against jaundice, the discovery has led us ...

"The gene variant codes for an enzyme that has not previously been linked to the metabolism of bilirubin. Although the enzyme itself does not protect against jaundice, the discovery has led us ...