This study describes experiments that support the novel hypothesis that reprogramming skeletal muscle to a pro-regenerative state increases its ability for innervation. Specifically, transient ...

SIRT5, a "longevity protein," plays a crucial role in delaying age-related skeletal muscle decline by modulating inflammatory pathways through its interaction with TBK1. In a primate model, SIRT5 ...

Conversely, reduction in satellite cell content and function is a significant contributor for skeletal muscle wasting in many conditions, including aging and degenerative muscle disorders ...

Hirai DM, Tabuchi A, Craig JC, Colburn TD, Musch TI, Poole DC. Regulation of capillary hemodynamics by KATP channels in resting skeletal muscle. Physiol Rep 2021; 9(8):e14803. Ferguson SK, Woessner MN ...

The same biological processes that drive aging — such as energy loss — may also contribute to lung diseases like chronic ...

Age, method, sample size, sex and tissue variation could elevate effect size bias. Data synthesis Only skeletal muscle gene networks including imprinted genes were reported. Exercise-associated effect ...