Cysts, fibrosis, and tubular degeneration form the typical triad of pathologies leading to the gradual decline in kidney ...

Research led by Children's Hospital of Fudan University in China has found that a gene called pancreatic progenitor cell differentiation and proliferation factor (PPDPF) helps protect kidney cells by ...

Moreover, the cells and soluble factors participating in this response in liver are also similar to those in parenchymal injury to kidney, lung, or skin. Fibrosis occurs earliest in regions where ...

Researchers have identified type 5 collagen as a key factor in kidney fibrosis, revealing its potential as a biomarker to predict chronic kidney disease progression. A repurposed anti-cancer drug, ...

New research led by Unity Health Toronto that examines how fibroblast cells in the body are activated to cause fibrosis and organ scarring has been published in Nature Reviews Molecular Cell Biology.

New research has revealed that removing a protein called gasdermin D can protect the liver from inflammation and scarring in ...

9, 2025 — Researchers have identified type 5 collagen as a key factor in kidney fibrosis, revealing its ... specialized cells in the renal filter, even ... A Diabetes, Heart Failure, and Kidney ...

New UCLA research conducted using mouse models and human genetic data has uncovered a critical factor that determines how much scarring occurs following kidney injury, leading scientists to identify a ...

fibrosis, and cellular death and degeneration. Its role in PKD had never been examined before. Tsiokas speculated that by genetically deleting Fbxw7 in a mouse model used to study kidney function ...

Fibroblast cells do this to close wounds, but the process can cascade in unwanted places. Examples include cardiac fibrosis; kidney or liver fibrosis, which precedes cancer; and pulmonary fibrosis ...