In cholestasis, the flow of bile juice from the liver to the small intestine reduces or stops. As a result, bile builds up in the liver, and bile acids eventually enter the bloodstream.

Cholestasis induced by inflammation is a common complication in patients with extrahepatic infections or inflammatory processes, generally referred to as sepsis-associated cholestasis.

Cholestasis affects about 1 out of every 100 pregnancies. Cholestasis occurs in about 1% of pregnancies in the United States. There are a few factors that increase a person's risk.

Intrahepatic cholestasis of pregnancy (ICP), which is diagnosed by elevated maternal levels of serum bile acids and associated with pruritus, affects 0.5–2.0% of pregnant women and occurs ...

Odevixibat treatment reduced levels of peripheral blood autotaxin, pruritus and serum bile acid among pediatric patients with progressive familial intrahepatic cholestasis, according to pooled ...

Obstetric cholestasis is also slightly more common among women of Indian-Asian or Pakistani origin with three in 200 (1.5%) of women affected. These facts support a genetic cause.

In a video exclusive, Marlyn Mayo, MD, of the University of Texas Southwestern Medical Center, reported long-term treatment with seladelpar was safe and well-tolerated in reducing markers of ...

Sometimes, a friend's Facebook comment can save a life. After Christina DePino complained in a Facebook post about itching during her pregnancy, friends cautioned that she may have cholestasis ...

Is Neonatal Cholestasis a Marker of Future Liver Damage? —This study examined the natural history of infants born with alpha-1 antitrypsin (AAT) deficiency and liver disease, with a focus on ...

Cholestasis of pregnancy is a disease that remains a bit of a conundrum. The syndrome, commonly known as intrahepatic cholestasis of pregnancy (ICP), is comprised of pruritis and elevated bile acids.

Sepsis-associated Cholestasis . It has been known for many years that patients with a wide variety of nonhepatic infections can develop cholestasis (see [15,76] for excellent reviews). In 1901, in ...

Intrahepatic cholestasis (ICP, also known as obstetric cholestasis) is a condition of pregnancy that commonly manifests as itching and in rare cases jaundice. It is important to evaluate the cases ...