You’ll then stay on topical treatments long-term to keep breakouts away. People with especially severe cystic or nodular acne may need to use doxycycline for longer periods of time. Each case is ...

Oral antibiotics generally used in the treatment of acne are doxycycline, erythromycin, minocycline, sulfamethoxazole-trimethoprim, and tetracycline. Antibiotics reduce P. acnes levels.