Stimuli driving stellate cell activation include hepatocellular necrosis due to oxidant stress, apoptosis, and soluble growth factors. Specific lymphocyte subsets can also stimulate fibrogenesis.

[97] Complete necrosis was obtained in 69% of HCC 2 ... is currently the most common approach for the management of hepatocellular carcinoma (HCC) without curative options. TACE consists of ...