Hyperacute rejection most commonly occurs while the patient is still in the operating room; the kidney frequently turns black before the surgical team's eyes. Antibody-to-transplant antigens can ...

In mid-2024, the patient underwent a kidney transplant. Though he was relatively young for a transplant, that’s not where he ...

“This work demonstrates that a pig kidney ... triggers hyperacute rejection may be enough, along with clinically approved immunosuppressive drugs, to successfully manage the transplant in ...

Cyclosporine, generally introduced in the 1980s, was a breakthrough in preventing rejection and opened a new era in transplant surgery. In 1986 alone, for example, nearly 9,000 kidney transplants ...

The recipient was Tim Andrews, a 66-year-old New Hampshire resident who had end-stage kidney disease and was on dialysis for ...

However, this type of rejection is common in human kidney transplants ... genes to the pig used in the transplant and remove ...

The first clinical trials using organs from genetically modified pigs offer hope to patients with kidney failure, who face a ...

Thirty years ago, I spoke at a conference on xenotransplantation — the transplantation ... attached a kidney from a pig that had been genetically engineered to avoid immunologic rejection ...

Transplant performed at Massachusetts ... Elimination of three glycan antigens to prevent hyperacute immune rejection 2) Insertion of seven human transgenes to regulate immune response, reduce ...

If an ABO-incompatible graft is transplanted, hyperacute rejection will occur (the possible exception being a liver graft). In kidney transplantation, preformed circulating cytotoxic antibodies in ...