The medication's acne-fighting benefits have been backed by science for decades, but it’s important to be aware of a few ...

Isotretinoin is indicated for nodular acne or severe acne that is unresponsive to conventional therapies. The usual dose is 0.5 to 1.0 mg/kg/day for 20 weeks, or a cumulative dose of 120 mg/kg.

The iPLEDGE program is a risk management system mandated by the U.S. Food and Drug Administration to prevent fetal exposure to isotretinoin, a medication used for severe acne that doesn’t ...

"I typically prescribe around 1 mg/kg/day or a little ... after completion of isotretinoin. They included 19,907 patients in their study. Mean age was 20.6, and 52.8% were female.

Ekaterina Demidova Ekaterina Demidova/Getty The iPLEDGE program is a risk management system mandated by the U.S. Food and Drug Administration to prevent fetal exposure to isotretinoin, a ...