Mitochondria are cell organelles surrounded by a double membrane. In addition to numerous essential functions in the ...

Elizabeth Jonas first got interested in mitochondria by chance. In 1995, she was a postdoctoral researcher at Yale, working ...

Mitochondrial ATP synthase is composed of dimers that, when come together, form membrane curvature that is essential for efficient energy conversion. While the mitochondrial signature lipid ...

F1FO-ATP synthase is critical for mitochondrial functions. The deregulation of this enzyme results in dampened mitochondrial oxidative phosphorylation (OXPHOS) and activated mitochondrial ...

Exome analysis revealed a de novo heterozygous variant in ATP5F1B, which encodes the β subunit of mitochondrial ATP synthase (also called complex V).

They identified the molecular target of J147 as a mitochondrial protein called ATP synthase that helps generate ATP—the cell’s energy currency—within mitochondria. They showed that by manipulating its ...

Structural studies of a mitochondrial ATP synthase illustrate the basis for the diversity of its membrane-shaping properties.

ATP, the fuel of life, is produced in mitochondria of living cells by a molecular machine, the ATP synthase. We have isolated the machines from four fungal species, compared their stabilities and ...

Each year, about 1,000 to 4,000 children in the United States are born with a mitochondrial disease. Many of these diseases are tied to a deficiency in ATP synthase thought to be triggered by ...

High-resolution microscopy revealed P5CS segregation from ATP synthase. Interactions between P5CS and ATP synthase complexes were confirmed, and mitochondrial membrane potential was assessed.

Using a similar approach but a different protein extraction protocol, Tsuji et al. identified the ATP synthase β-chain (OxPhos complex V) as increased and the isocitrate dehydrogenase (NAD) α ...