Cysts, fibrosis, and tubular degeneration form the typical triad of pathologies leading to the gradual decline in kidney ...

Researchers have identified type 5 collagen as a key factor in kidney fibrosis, revealing its potential as a biomarker to predict chronic kidney disease progression. A repurposed anti-cancer drug, ...

A series of experiments in mouse models confirmed these findings: mice with low Col5a1 developed more severe fibrosis and ...

Key takeawaysUCLA researchers have identified type 5 collagen as a key factor in kidney fibrosis, revealing its potential as ...

Kidney samples were collected from both mouse models and previously published human datasets ... and reduced markers of ...

The three key functions of the Core are listed below: These CF mouse models produce no functional Cftr mRNA or protein, and are particularly useful to stufy consequences of the electrophysiological ...

A comprehensive proteomic map of liver fibrosis progression and healing in two mouse models identifies etiology-specific extracellular matrix components, laying the foundation for targeted ...

fibrosis, and cellular death and degeneration. Its role in PKD had never been examined before. Tsiokas speculated that by genetically deleting Fbxw7 in a mouse model used to study kidney function ...

Professor Kenji Osafune (Department of Cell Growth and Differentiation) and his team of researchers have devised an effective ...