Patterning of the nephron along the proximal–distal ... and the developmental defects found in human patients. Induction of the kidney occurs through reciprocal interactions between an ...

These important genetic associations identified in human renal hypoplasia have ... in the MM leading to a 50% decrease in both kidney size and nephron number in adult mice (33).

Using a mouse model of AKI, the research team first demonstrated the therapeutic potential of human iPS cell-derived nephron progenitor cells (hiPSC-NPCs). When these cells were transplanted into the ...