Although not specifically approved for the treatment of bleeding peptic ulcers, proton pump inhibitors (PPIs) such as omeprazole (Losec AstraZeneca, Luton, UK) are widely used for this indication.

After 30 minutes in the phosphate buffer solution, 96% of the total omeprazole was released (mean from six capsules). The caplets of the test product, on the other hand, disintegrated within 12 ...

Objective: To investigate the relative bioavailability and bioequivalence, in fasting and fed conditions, of repeated doses of two omeprazole enteric-coated formulations in healthy volunteers.