Dobrolecki LE, Lewis MT. Surgical Procedure for Implantation of Human Tumor Tissue into the Epithelium-Free Mammary Fat Pad of Immunocompromised Mice to Generate Patient-Derived Xenografts (PDX).

“The assumption is that what grows out in the PDX is reflective of the bulk of the tumor in the patient,” study author and cancer geneticist Todd Golub, of both the Broad Institute, at MIT, and ...

The complexity of the TME in vivo limits the conclusions that can be drawn from in vivo models. Optimizing cell culture ...

These patient-derived xenografts (PDX) already have a history in translational research – investigators use them as tools for understanding tumour biology in preclinical studies. 1 Usually the ...

Expression data from patient-derived xenograft (PDX) mouse models exposed to micvotabart pelidotin (MICVO) indicate gene signatures associated ...

These patient-derived xenografts (PDX or “xenolines”) are representatives of the patient’s tumor but with the advantage that they are testable model systems. We are evaluating ways to use high content ...

Verastem Oncology (Nasdaq: VSTM), a biopharmaceutical company committed to advancing new medicines for patients with RAS/MAPK ...

Targeted therapies have significantly improved outcomes for patients with non-small cell lung cancer (NSCLC) with actionable mutations. However, many tumors inevitably develop drug resistance and ...

The primary focus Patient-Derived Xenograft (PDX) Core is to develop, and provide to the Baylor PDX community, computational and bioinformatics infrastructure to support large scale generation, ...