Dobrolecki LE, Lewis MT. Surgical Procedure for Implantation of Human Tumor Tissue into the Epithelium-Free Mammary Fat Pad of Immunocompromised Mice to Generate Patient-Derived Xenografts (PDX).

“The assumption is that what grows out in the PDX is reflective of the bulk of the tumor in the patient,” study author and cancer geneticist Todd Golub, of both the Broad Institute, at MIT, and ...

Participants expressed that they would sacrifice an unlimited number of mice for their child, yet only 63% endorsed a willingness to use up to 1,000 mice per patient. Willingness to use more mice ...

A precision medicine workflow integrating proteomics and personalized xenograft models was developed and applied to an adolescent with progressive SETTLE tumor. Target identification combined with pre ...

1 Unlike patient-derived tumor xenografts, 3D models eliminate cross-species incompatibilities and offer greater control over experimental conditions. Compared to 2D cultures, where cells proliferate ...

These patient-derived xenografts (PDX or “xenolines”) are representatives of the patient’s tumor but with the advantage that they are testable model systems. We are evaluating ways to use high content ...

AUTX-703, a novel and potent oral KAT2A and KAT2B protein degrader, inhibits growth and induces profound, persistent cell state differentiation in SCLC modelsNEWTON, Mass., April 03, 2025 (GLOBE ...

The primary focus Patient-Derived Xenograft (PDX) Core is to develop, and provide to the Baylor PDX community, computational and bioinformatics infrastructure to support large scale generation, ...