Vigabatrin is indicated as monotherapy for children with infantile spasms and as adjunct therapy for adults ... eliminated primarily by renal excretion as an unchanged drug and has an elimination ...

Only 2.5% of patients with end-stage renal disease undergo kidney transplantation as initial renal replacement therapy, despite evidence that transplantation is most effective when implemented ...

Renal replacement therapy (RRT) is a life-saving treatment for patients with impaired kidney function, which affects their ability to flush and store fluids. In situations where the kidneys are ...

Replacement therapy: may be substituted for the titrated components. Severe renal impairment: titrate slower. ≥75yrs, or hepatic impairment: not for initial use (initially use amlodipine alone ...

Hemodialysis (HD)-related factors also alter drug clearance. Vigabatrin: in patients with renal impairment the dose should be decreased based on creatinine clearance. The effect of dialysis on ...