Brendan Lee, M.D., Ph.D., is the director of the lab. We are interested in the consequences of gene mutations on skeletal development and homeostasis. We combine studies on mammalian tissue and organ ...

Impairment in the skeletal muscle's capacity to efficiently use or store glucose can disturb overall glucose homeostasis, potentially resulting in insulin resistance—a major risk factor for type ...

Human adults do not have significant amounts of BAT, so the team looked at human skeletal muscle—vital for energy homeostasis in humans. In both human muscle cells and mouse brown adipocytes ...

Such skeletal muscle anaerobiosis ultimately prevented the neutralization ... causing a catastrophic failure of intracellular homeostasis. This paper addresses six hallmark physiological requirements ...