and that the centrosomes nucleate the growth of the spindle microtubules. During mitosis, many of the spindle fibers attach to chromosomes at their kinetochores (Figure 6), which are specialized ...

Cell division is essential to the propagation of life. During cell division, mitotic spindles segregate duplicated chromosomes with high fidelity. Spindle structure depends on the proper polar ...

Same as in mitosis, except that the spindle fibers from each centriole attach to one chromosome of a matching chromosome pair. In other words, the fibers from one centriole attach to 23 ...

HDAC6 is upregulated in corneal diseases and causes ENKD1 deacetylation at lysine 98. Deacetylation of ENKD1 blocks its ...

During mitosis spindles attach a special structure of chromosome, which is called "centromere." In this study, we clarified how centromeres are formed on chromosomes. Advanced Search ...

It has been known for decades that chromosomes attach to a bipolar structure called the mitotic spindle that is composed of microtubules. Mitosis is the process by which a cell divides its nucleus ...

A hallmark of tumor cells is an inability to control their proliferation, which implies that these cells are capable of bypassing cell cycle checkpoints and regulation by tumor suppressor signaling ...

E.R. Steuer, L. Wordeman, T.A. Schroer, M.P. Sheetz, "Localization of cytoplasmic dynein to mitotic spindles and kinetochores," Nature, 345:266-68, 1990. Michael ...

In mammals, several NEKs—including NEK2, NEK6, NEK7, and NEK9—localize to centrosomes, the microtubule-organizing centers (MTOCs) responsible for forming the mitotic spindle. These centrosomes ...

It can be seen in the stages shown above that mitosis maintains the chromosome number or complement of a cell. Mitosis therefore maintains the chromosome complement and ensures that each daughter ...

A large structure called the mitotic spindle also forms from long proteins called microtubules on each side, or pole, of the cell. During prometaphase, the nuclear envelope that encloses the ...

This spindle is made of fibers. The centrioles begin to separate. The activities are the same as in mitosis, except that in this cell the chromosomes attach to the membrane of the nucleus and then ...