The patient was also taking topiramate for two months before being hospitalized for his seizure disorder. His dosage was increased after admission, but no changes were made to his other medications.

[22,23] Indeed, after a mean period of 27.5 months ... in whom a mean of eight drugs administered before topiramate treatment had been ineffective. Moreover, further clinical studies are needed ...

Topiramate, an antiepileptic drug with potential mechanisms of action including sodium channel blockade, inhibition of glutamate receptors, and enhancement of γ-aminobutyric acid (GABA ...

Toplak and colleagues, therefore, investigated the efficacy and safety of topiramate as an antiobesity medication in patients with diabetes. After 24 weeks, weight losses of 4.5% and 6.5% were ...