Topiramate, an antiepileptic drug with potential mechanisms of action including sodium channel blockade, inhibition of glutamate receptors, and enhancement of γ-aminobutyric acid (GABA ...

The anticonvulsant topiramate causes dose-dependent weight loss in humans and in animal models of diabetes. Toplak and colleagues, therefore, investigated the efficacy and safety of topiramate as ...

Topiramate is a new anticonvulsant with proven efficacy in migraine and other conditions, which reportedly confers weight loss in patients receiving doses up to 300 mg/day. Objective: The aim of ...