Key New Findings Initial validation using orthotopic models: SIL204 administered subcutaneously (systemically) showed ...

The primary focus Patient-Derived Xenograft (PDX) Core is to develop, and provide to the Baylor PDX community, computational and bioinformatics infrastructure to support large scale generation, ...

A novel, allosteric and highly potent USP1 inhibitor, LAE120 exhibits robust tumor inhibitory activity across various xenograft models Significantly accelerated the progress of drug discovery ...

For human xenograft experiments in mice and administration of primary human material not suspected of harboring a human pathogen, standard ARP handling practices for housing and cage changing can be ...

Nemati and colleagues assessed whether the genes involved in response to topotecan-based chemotherapy in a panel of human SCLC xenografts could be useful for guiding future clinical assessment.