News

C&EN5d
Oxidative Stress, DNA Damage, and Inflammation Induced by Ambient Air and Wood Smoke Particulate Matter in Human A549 and THP-1 Cell Lines
Combustion of biomass and wood for residential heating and/or cooking contributes substantially to both ambient air and indoor levels of particulate matter (PM). Toxicological characterization of ...
C&EN17d
Discovery of a Small-Molecule Modulator of the Autophagy-Lysosome Pathway That Targets Lamin A/C and LAMP1, Induces Autophagic Flux, and Affects Lysosome Positioning in Neurons ...
Autophagy is a major catabolic degradation and recycling process that maintains homeostasis in cells and is especially important in postmitotic neurons. ... A549 cells were plated at a density of 2.5 ...
The EMBO Journal22d
Small molecule disruption of RARα/NCoR1 interaction inhibits chaperone-mediated autophagy in cancer
AbstractChaperone-mediated autophagy (CMA), a type of selective degradation of cytosolic proteins in lysosomes, is commonly upregulated in cancer cells, ... A549 cells were plated on 12-well glass ...
The EMBO Journal22d
Small molecule disruption of RARα/NCoR1 interaction inhibits chaperone-mediated autophagy in cancer
Autophagy is the cellular process of lysosomal degradation and recycling of cytosolic components, providing a cellular quality control mechanism and allowing for maintenance of cellular homeostasis ...
SciELO27d
RBBP4 downregulation increases the sensitivity of A549 and HeLa cells to cisplatin by inhibiting cyclin D1 expression - SciELO - Brasil
Downregulation of RBBP4 enhanced cisplatin sensitivity in A549 and A549/DDP cells. ... the role of autophagy. Int J Mol Sci. 2024;25(8):4377. 21 Liang R., Xiang Y., Hu C., Tang X. Expression and ...