Mushrooms found in the forests of Bankura and Birbhum in West Bengal could become a game-changer in cancer treatment.

In A549 lung cancer cells, Rig-G overexpression significantly suppressed p53 downstream genes. Upregulation of Rig-G promoted the expression of E-cadherin and p21, enhancing cell adhesion and growth ...

Icaritin (ICA) is a prenylflavonoid natural product extracted from plants of the Epimedium genus. The approval of ICA softgel capsules as a class 1.2 traditional Chinese medicine (TCM) innovative drug ...

Conversely, proteins associated with “cell cycle” and “p53 pathway,” including SFN, showed a persistent increase starting at 3 h and peaking at 48 h. Western blotting and immunohistochemistry ...

UPMC Hillman Cancer Center, University of Pittsburgh, 5115 Centre Ave, Pittsburgh, Pennsylvania 15232, United States Department of Computational and Systems Biology, University of Pittsburgh, 3420 ...

Objective: The aim of the study was to improve the therapeutic effect for lung cancer using a synergetic strategy of adenovirus-based gene therapy combined with ...

Here, the authors developed a cell-based screening assay for the identification of small molecule inhibitors of nonsense-mediated decay (NMD), and used it to validate KVS0001, a new small molecule ...

P53 in the Mitochondrial Shaping Protein-Regulated Chemotherapy Figure 3 Mitophagy and p53 in mitochondrial shaping protein-regulated chemotherapy. In chemosensitive cells, cisplatin-induced DNA ...