“The tropism of natural AAV serotypes is limited,” he says. “They also tend to infect the liver, which can cause severe side effects in some cases.” Improving AAV tropism could offer ...

Underpinning Voyager’s mission is its trademark AAV capsid-discovery platform ... promise for producing candidates with enhanced tropism for liver, eye, and other tissue types (Fig.

Amid a reckoning for the gene therapy field, Vertex Pharmaceuticals has joined a growing list of companies paring back their ...

AAV4 also mostly avoids the liver, a major target organ for most ... Walkey et al, A comprehensive atlas of AAV tropism in the mouse, Molecular Therapy (2025). DOI: 10.1016/j.ymthe.

Tropism-modifying strategies. Various methods have been employed to detarget the virus from its inherent liver tropism or evade phagocytosis by Kupffer cells. Bypassing these host interactions ...

Recently, several techniques have been developed to enhance vector tropism, such as genetically inserting peptides on the AAV capsid to modify their interactions with known cell receptors. While this ...