Non-alcoholic fatty liver disease (NAFLD) is a hepatic metabolic syndrome resulting from lipid metabolic imbalance.

Non-alcoholic fatty liver disease (NAFLD) is a hepatic metabolic syndrome resulting from lipid metabolic imbalance.

This finding indicates that the IRF8/BMAL1/ PPARγ axis may play an important role in liver lipid metabolism. Furthermore, adeno-associated virus-mediated IRF8 knockdown in mouse liver markedly ...

Working together, the pair showed they could improve the vision of mice born with genetic blindness ... the scientists modified an adeno-associated virus (a small virus that’s harmless to ...

We will use an AAV expressing AOAH to test this idea ... To achieve this, they utilized whole-body Aoah-/-mice. The authors demonstrated that AOAH reduced LPS-induced lipid accumulation in the liver, ...

Once the liver appeared pale, the perfusion solution was switched ... For the experiments with AAV-scr or AAV-siTet2, HFD mice were infected with the respective virus for 10 days. The Student’s t-test ...

Tune’s treatment is delivered by a lipid nanoparticle to hepatocytes in the liver, where the hepatitis B virus replicates ... ‘When you use an [adeno-associated virus] to deliver to the muscle, that ...

But, finally, last year, a new paper was published by scientists at the company showing that targeted partial reprogramming of age-associated cell states successfully extended the lifespan of mice ...