Utilizing a filamentous fungus in the gut microbiome may provide a new strategy for treating metabolic dysfunction-associated ...

Solid Biosciences Inc. (Nasdaq: SLDB), a life sciences company developing precision genetic medicines for neuromuscular and ...

A drug candidate, previously successful at treating severe fatty liver disease, reduces atherosclerosis - a primary driver of cardiovascular death worldwide - in large mammals, a study suggests.

Non-alcoholic fatty liver disease (NAFLD) is a hepatic metabolic syndrome resulting from lipid metabolic imbalance.

Non-alcoholic fatty liver disease (NAFLD) is a hepatic metabolic syndrome resulting from lipid metabolic imbalance.

An “inverse vaccine” that delivers deactivated allergens to the liver was able to reduce reactions in mice with allergic asthma for at least a year after treatment. Should the approach ...

Liver-directed AAV-based gene therapy offers promise for people living with hemophilia B or other genetic disorders. 6,7,11–18 However, the long-term safety and efficacy of this approach remain ...

Once the liver appeared pale, the perfusion solution was switched ... For the experiments with AAV-scr or AAV-siTet2, HFD mice were infected with the respective virus for 10 days. The Student’s t-test ...

In the study, published in Circulation Research, the CNIC team developed a gene therapy using adeno-associated viruses (AAV)—a safe delivery ... of the experimental mice. The results are ...

We thank Dr. Renjie Chai and Dr. Joe Burns for providing AAV-ie-K558R capsid plasmid and mScarletand Yap5SA-t2a-mScarletoverexpression constructs respectively. We thank Dr. Aaron Nagiel for helpful ...

The global humanized liver mice model market is on a strong growth trajectory, fueled by the increasing prevalence of liver diseases and significant technological advancements in genetic engineering.