fumigatus, azole-resistance represents a clinically ... the same problem may affect other antifungals with novel mechanisms of action that are in development. For example, the medical antifungal ...

Scientists have discovered that the most widely-used class of antifungals in the world causes ... weapons against fungal plant diseases are azole fungicides. These chemical products account ...

Fluconazole, a very safe and effective azole antifungal, requires a much higher dose in children (12 mg/kg/day) compared with adult patients. In addition, the neonatal field is exploring ...

The last time a new class of oral antifungal was launched was the azoles – in 1985 with the launch of the now withdrawn ketoconazole. A new azole antifungal isavuconazole (Basilea Pharmaceutica) was ...

More information: Elevated mutation rates in multi-azole resistant Aspergillus fumigatus drive rapid evolution of antifungal resistance, Nature Communications (2024).

The mechanism of action of citalopram HBr as ... potent inhibitors of CYP2C19 or CYP3A4 (eg, azole antifungals). May be antagonized by carbamazepine. Increases metoprolol levels.

Since mid-2002, two new antifungal drugs — voriconazole, a third-generation azole, and caspofungin ... efficacy (because of their specific mechanisms of action), more favourable toxicity ...