Poster E0055: High-dose isavuconazole therapy is well-tolerated and significantly improves survival in a fruit fly model of invasive mucormycosis – S. Wurster, N. D. Albert, N. P. Wiederhold, R. E.

To combat long-overlooked fungal pathogens, researchers and regulators must embrace innovative science and policy.

tropicalis and other fungi are of growing concern as many of these pathogens are becoming increasingly resistant to antifungal medicines. However, the biological mechanisms underlying this ...

The study demonstrates that this RNAi approach shuts down vital fungal genes, thereby inhibiting pathogen growth - a groundbreaking step in the development of new antifungal therapies. (Nanowerk News) ...

The MIC values of the azole antifungals and 5-FC were defined as the minimum drug concentration at which visual growth was determined to be 50% relative to that of the growth control, known as MIC 50.

We evaluated the cardiac effect of azole antifungals, specifically ITZ, and possible mechanisms of toxicity. Ex vivo live-heart studies were performed utilizing Sprague Dawley rats. Short exposure (5 ...