Only three classes of antifungal drugs are available to treat disease, and only one class, the azoles, is suitable for long-term oral administration. Resistance to azoles is spreading due to the ...

The effect on clinical outcomes is difficult to assess in this patient population and more studies are needed to better understand the safety of azoles given in the context of other QTc prolonging ...

A new study suggests that adding common bone loss drugs to azoles can improve efficacy when treating fungal infections. Human skin, hair and nails are all vulnerable to fungal infections.

These azoles antifungals target a crucial enzyme for sterol biosynthesis, called CYP51. While not fungi, both Leishmania species have biochemical similarities to fungi in their plasma membrane ...

They're also often resistant to treatments, including a common class of antifungals called azoles. A study published in mSphere points to a new way to boost the efficacy of azoles in treating ...

These infections often develop resistance to azoles, a common anti-fungal treatment. A new study suggests that adding common bone loss drugs to azoles can improve efficacy. In lab tests ...