Scientists say they have new experimental evidence of a novel role for bilirubin, a natural yellow pigment found in the body, ...

Cardiac metabolic dysfunction is a hallmark of heart failure (HF). Estrogen-related receptors ERRα and ERRγ are essential regulators of cardiac metabolism. Therefore, activation of ERR could be a ...

Purpose: To analyze the relationship between physiological serum total bilirubin (STB) concentrations and the progression of diabetic nephropathy (DN). Methods: The clinical features and pathological ...

Figure 1. Metabolic regulation by macrophages. Macrophages regulate local and organismal metabolism at different levels. At the organismal level, macrophages control metabolite availability by ...

Kim M, Brustad N, Eliasen AU, Ali M, Wang T, Rasmussen MA, Ernst M, Hougaard D, Litonjua AA, Wheelock CE, Kelly RS, Chen Y, Prince N, Townsend PA & Stokholm J (2024) Bilirubin metabolism in early life ...

Figure 1. Metabolism of bilirubin in the body: Heme is decomposed by HO-1 (reticuloendothelial system) to produce bilirubin, which is then converted into indirect bilirubin by bilirubin reductase.

In this editorial, the authors describe the foundations of an N-of-1 gene-editing study to treat an infant with a urea-cycle disorder. 2 Department of Chemistry and Biochemistry, University of ...

Secondary metabolites are a reliable and very important source of medicinal compounds. While these molecules have been mined extensively, genome sequencing has suggested that there is a great deal ...