The use of an aryl boronic acid carbonyl warhead to target a noncatalytic lysine side chain enables the development of covalent inhibitors against the anti-apoptotic protein myeloid cell leukemia ...

Potent therapeutic 'warheads' that target cancer cells designed Date: May 10, 2016 Source: The Scripps Research Institute Summary: In a pair of related studies, chemists have identified and ...

In fact, from 2013-2021, eight drugs utilizing targeted covalent inhibitors (TCI) to treat lymphoma, lung cancer, and breast cancer have been approved. Today, scientists have designed “warheads” with ...