Maraviroc acts as a highly selective and potent inhibitor of CCR5-tropic virus and has been shown to lack efficacy in patients with dual- or mixed or CXCR4-tropic virus. [9, 10, 11] Thus, the ...

Gene vs allele Genes are chunks of DNA that contribute to particular traits or functions by coding for proteins that influence physiology. Alleles are different versions of a gene, which vary ...

The protective allele was linked to higher expression of the HLA-C gene, although other gene variants leading to differential levels of gene expression were not associated with viral control. [58 ...

Peptide ligands presented by human leukocyte antigen (HLA) molecules on the cell surface represent the immunopeptidome that could be utilized for identification of antigenic peptides for immunotherapy ...

2 Current advances in integrating gene editing with immunotherapy for HIV For R5-tropic HIV-1 strains—which dominate during the early and chronic phases of infection—C-C chemokine receptor 5 (CCR5) is ...

Target engagement can be measured by developing an assay where a ligand is added to the target protein and a quantifiable readout is generated, proportional to the degree of protein–ligand interaction ...

Objective Gut homing of lymphocytes via adhesion molecules has recently emerged as new target for therapy in IBDs. We aimed to analyse the in vivo homing of effector (Teff) and regulatory (Treg) T ...