Untargeted and targeted metabolomics revealed distinct upregulation of 1-carbon metabolism during CD4 + T-to-Tfh cell differentiation. Supplementation of amino acids essential for 1-carbon metabolism, ...

The mechanisms underlying this functional bias remain elusive. Previous studies have reported that CD4 + T cells from mice harboring DC-specific deletion of IL-27p28 display an increased capacity of ...

In our analysis, we observed a significant decrease in the total T cell reservoir in the spleens of aged mice; however, the distribution of CD4+ T cells and CD8+ T cells, as well as B cell populations ...

Indolent CD4+ cytotoxic chimeric antigen receptor (CAR) T-cell lymphoma involving the small intestine was diagnosed in a patient who had previously received ciltacabtagene autoleucel (cilta-cel) CA ...

We analyzed longitudinal peripheral blood samples by flow cytometry and targeted single cell RNA sequencing coupled to T cell receptor (TCR) sequencing. At the time of transplant, CD4 T cells from CMV ...

Combined CD4 and CD8 memory did not increase monocyte-derived dendritic cells; this combination recapitulated increases in neutrophil and inflammatory monocyte numbers in educated wild-type mice.

These findings led us to determine whether subpopulations of CD4 T cells existed that displayed markers of terminal differentiation or exhaustion during murine Mtb infection.