CD4 + and CD8 + T cells isolated from patients with low levels of HBsAg (<100 IU/mL) and in particular low levels of HBcrAg (<3 Log U/mL) were more responsive to PD-L1 blockade in vitro ... flow ...

ICB-resistant HCC has been primarily associated with an immunosuppressive tumour microenvironment (TME), characterised by myeloid-derived suppressor cell (MDSC) expansion and CD8 + T cell dysfunction.

In particular, we sought to elucidate how different ratios of these components loaded in degradable polymer particles shape the antigen presenting cell (APC) -T cell interactions that drive ...

Adding the TCRA or TCRB 3' UTR to an anti-CD19 chimeric antigen receptor (CAR) improves the ability of the corresponding CAR-T cells to kill tumor cells in vitro. Here, we identified mRNAs that ...

The data analysis is rigorous and the experiments performed are appropriate. The findings of the manuscript will expand upon previous findings of a role for histone deacetylase 3 in thymocyte ...

CD4+ T cell enrichment was performed using EasySep human CD4+ T cell isolation kit (Stem Cell Technologies, United States). Cells were routinely checked for purity of above 96% as detected by flow ...