Drug-induced liver injury including cholestasis is another form of acquired liver disease, accounting for approximately 2 to 5% of hospitalizations for jaundice, 10% of cases of hepatitis in all ...

Mirum Pharmaceuticals, Inc. today announced that the U.S. Food and Drug Administration (FDA) has approved a new tablet formulation of LIVMARLI® (maralixibat) for the treatment of cholestatic pruritus ...

However, often the onset of hepatic injury by drugs may be delayed from days to several months. Liver biopsy is not performed in every single instance of drug-induced cholestasis. However ...

Importantly, there were no events of liver injury, cholestasis, or hemolysis across all participants, and there were no serious adverse events (SAEs) in the Phase 1 trial. SEP-786 was Septerna's ...

Forty patients with cholestatic liver disease and pruritus admitted to the department ... 2.2. Ranking Criteria Inclusion criteria: 1) meet the diagnostic criteria for cholestasis [11]; 2) pruritus ...

Pfizer said it will stop development of an oral weight-loss pill after a participant taking the drug in a clinical trial ...

drug-induced liver injury, alcohol-related liver disease, and viral hepatitis. In turn, such work could accelerate drug development and other approaches to restore liver health. Longer-term ...

Ferroptosis plays an essential role in chronic liver diseases, and cyclooxygenase-2 (COX-2) affects liver fibrosis through multiple mechanisms. + ...

drug-induced liver injury, alcohol-related liver disease, and viral hepatitis. And it could also help accelerate the development of therapies that restore liver health. For example, the organoids ...

However, research on COX-2 regulation of ferroptosis in chronic liver injury remains limited. This study aimed to investigate whether and how COX-2 regulates ferroptosis in chronic liver injury.