T cell clonal anergy is mediated by Egr2 but its downstream effectors have not been characterized. Here the authors show that Egr2 activates Ndrg1, which is critical for the anergy state, while ...

T cell anergy has been correlated with defective signaling by the GTPase Ras, but causal and mechanistic data linking defective Ras activity with T cell anergy are lacking. Here we used adenoviral ...

Proposed by Gustav Nossal, the “Clonal Anergy theory” suggests that reactive T- or B-cells become deactivated during development and fail to increase immune responses.

T cells that lose their ability to proliferate in response to antigen stimulation are said to be anergic. Anergy occurs under several different circumstances, suggesting that T cells are poised to ...

The reactions to the intracutaneous injections of five antigens and histamine were studied in 114 persons, of whom 33 were patients with Hodgkin's disease, 64 were controls and the remainder had ...

The significance of the tuberculin test in patients with active or latent tuberculosis has received considerable study in the past, and interest in this subject has been revived since the advent of ...

In January, ETH Zurich has won the Swiss Watt d’Or Energy Prize for its anergy Grid and the dynamic underground storage system at the Hönggerberg campus. The Watt d'Or is considered a seal of quality ...