LACE 2.0 is a new release of the LACE R Bioconductor package. LACE 2.0 is capable of performing clonal evolution analyses for single-cell sequencing data including longitudinal experiments. LACE 2.0 ...

School of Pharmacy and Pharmaceutical Sciences, Trinity College Dublin, the University of Dublin, College Green, Dublin 2 D02 PN40, Ireland Trinity Translational Medicine Institute, Trinity College ...

FastBCR emerges as a efficient computational approach tailored for inferring B cell clonal families from massive datasets of BCR heavy chain sequences. In addition to its clustering capabilities, the ...

Adopting a culture system for expansion and differentiation of B cells developed by Kitamura and colleagues, we established a clonal B cell expansion protocol using 3T3 fibroblasts stably transfected ...

Clonal evolution represents the natural process through which cancer cells continuously search for phenotypic advantages that enable them to develop and expand within microenvironmental constraints.

We therefore performed an analysis of paired heavy and light chain B-cell receptor (BCR) repertoires in 12,591 HIV-1 envelope-specific single memory B-cells to determine alterations in the BCR ...