such as frameshift mutations – caused by a deletion or insertion in a DNA sequence that shifts the way the sequence is read – or missense mutations – alterations in the DNA that results in a different ...

The researchers found that a single mutation in the virus’s spike protein was enough to prevent it from attaching to human and horse cells. The mutation, however, still allowed the virus to enter and ...

A new study in Cell reveals that species living miles beneath the ocean’s surface have independently evolved the same genetic mutation. These species, which diverged on the tree of life millions ...

Nine patients with an ultra-rare form of amyotrophic lateral sclerosis (ALS) caused by mutations in the CHCHD10 gene were treated with an experimental antisense oligonucleotide (ASO) that’s designed ...

The study found that mutations to VPS35, a key player in this pathway, can prevent chemotherapy-induced cell death. These results could help pinpoint treatment-resistant tumors. Investigators at ...

Red arrows point to the individuals whom whole-exome sequencing was performed. Candidate mutations were validated by Sanger sequencing and the chromatograms were shown on the right. Red arrowheads ...

Widely used as a genome editing tool, the CRISPR-Cas9 system allows researchers to precisely induce frameshift mutations in specific genes or insert foreign nucleic acid sequences into a cell’s DNA.

The second family identified [NC_000017.11(NM_001042492.2):c.2739_2740del]. According to genotype-phenotype correlation analyses, proband with frameshift mutation tended to have a larger number of ...

Now, researchers have identified a possible genetic trigger that led to increased neuron production in that brain region, which is associated with higher-level cognition as well as impulse control and ...

Out of the 13 cases examined, 10 individuals with mutations in SCN1A were identified. They include 1 frameshift and 9 non-synonymous (seven missense and two non-sense) mutations. The authors concluded ...