How have scientists studied dynamic protein movements through the Golgi? One of the principal observations by Rothman's group was that the vesicles that formed in the Golgi moved cargo proteins ...

Trafficking occurs in both directions; the forward direction takes vesicles from the site of synthesis to the Golgi apparatus and next to a cell's lysosomes or plasma membrane. Vesicles that have ...

Evidence suggests that in Parkinson’s disease, a breakdown in lysosomal function allows lipids to build up within cells. Variants of the GBA1 gene, the strongest genetic risk factor for sporadic PD, ...

docking and fusing post-Golgi transport vesicles. To identify this machinery we are using two approaches. Firstly we are using a screening approach (RNAi or chemical) where we will make use of our ...