Luini and his colleagues observed procollagen only within Golgi cisternae, and never within the vesicles, which are normally much smaller (100 nm diameter) than procollagen (Bonfanti et al. 1998).

Quantitative measurements of intra-Golgi transport kinetics of diverse secretory cargos challenge the classic cisternal progression model and support the stable compartment model of the Golgi.

The Golgi apparatus identifies specific types of transport vesicle then directs them to where they are needed. Some proteins in the transporter vesicles could, for example, be antibodies.

When vesicles bud off from the trans-Golgi and fuse with endosomes, lysosomes are formed. In contrast, the ER is where the lysosomal hydrolases are synthesized.

All vesicles then detach from the endoplasmic reticulum through membrane fission and move to the endoplasmic reticulum–Golgi intermediate compartment (ERGIC). 8 From there, carriers containing ...

The proteins leave the Golgi wrapped in vesicles, bubbles of the organelle’s membrane. The function of the Golgi apparatus is well known, but its odd shape has long been a mystery.

Knockdown of any component of the complex saved the trans-Golgi vesicles. Rab7L1 appeared to play a crucial role in recruiting LRRK2 to the vesicles, as transfection with inactive Rab7L1 kept the ...

They then introduced the two drugs into yeast cells to inhibit the transport of specific protein-containing vesicles from the Golgi. By doing so, they expected to find out whether these vesicles are ...

"A consequence of this morphological difference is that vesicle transport between the ER and the Golgi stacks needs to be highly efficient and strictly regulated in order that vesicles do not get ...

Researchers at the University of Texas MD Anderson Cancer Center report that the Golgi apparatus may play a role in how lung cancer metastasizes. Their study, “Epithelial-to-Mesenchymal ...