Drugs in the carbapenem class like imipenem have become last-line treatments ... Klebsiella pneumoniae and Pseudomonas aeruginosa. Recarbrio’s reserved status means that it won’t be a big ...

emesis and diarrhea Imipenem–cilastatin 100 2 g 6 Rash, fever, nausea, emesis, diarrhea and seizures (risk of side effects often limits use) Aztreonam 200 8 g 6 Rash, fever and diarrhea ...

MSD took a similar approach with its Recarbrio (imipenem/cilastatin-relebactam) product, which was approved by the FDA for cUTIs and complicated intra-abdominal infections (cIAI) in 2019.

Doripenem was also found to be noninferior to imipenem in the treatment of ventilator-associated pneumonia and noninferior to piperacillin–tazobactam in the treatment of hospital-acquired pneumonia.

The MICs of ciprofloxacin and levofloxacin were determined by the broth microdilution method (Nucien Pharmaceutical Co., Ltd. Guangzhou, China) and interpreted according to Clinical and Laboratory ...