C57BL/6J male mice treated with AAV-IRF8 or AAV-GFP fed on CD (n = 6 biologically independent mice from two groups), and (D, E) C57BL/6J male mice treated with AAV-IRF8 or AAV-GFP fed on HFD (n ...

Of particular concern is the virus’s liking for the liver. “If you look at the number of ... and compared delivery efficiencies of the GFP molecules across the brain. AAV-PHP.B showed at least 40-fold ...